A familiar study on self-limited childhood epilepsy patients using hIPSC-derived neurons shows a bias towards immaturity at the morphological, electrophysiological and gene expression levels
Abstract Background Self-limited Childhood Epilepsies are the most prevalent epileptic syndrome in children.Its pathogenesis is unknown.In this disease, symptoms resolve spontaneously in approximately 50% of patients when maturity is reached, prompting to a maturation problem.The purpose of this study was to understand the molecular bases of this d